About the project

Welcome to Totally Integrated high-resolution Array cgh data and high-throughput sequencing Read data Archive (TIARA) human genome database on Genomic Medicine Institute (GMI), Seoul National University College of Medicine.

TIARA genome database, which contains personal genomic information obtained from heterogenous technologies including next generation sequencing (NGS) and ultra-high-resolution comparative genomic hybridization (CGH) arrays. This database improves the accuracy of detecting personal genomic variations, such as SNPs, short indels, and structural variants (SVs). Moreover, TIARA provides the genomic variants between whole genome sequencing and transcriptome sequencing for matched samples as well as the features of allele specific gene expression and transcriptional base modifications (TBM), or RNA editing. All data are concerned with our publications listed in "Publications" page.

(Sep.-2012) TIARA has provided the discovery of common and functional rare variants by adding more whole genome sequencing and transcriptome sequencing at high depth of coverage and the genomic variants between whole-genome sequencing and transcriptome sequencing for matched samples added functional consequences of human genomes, such as gene-expression levels, allele-specific gene expressions and transcriptional base modifications (TBMs) [5]. In this update, the variants based on human genome reference (hg19) are added.

(Sep.-2012) The genome browser of TIARA facilitates comparison of the genome and transcriptome sequencing results for individual humans, as well as simultaneous and efficient viewing of genomic variants from other high-throughput genome technologies.

(Nov.-2010) TIARA has been deposited the high-resolution array comparative genomic hybridization (CGH) data and whole-genome DNA sequencing data to obtain a comprehensive catalog of SNP(Single Nucleotide Polymorphism), Indel, CNV (Copy Number Variation) and SV (Structural Variation) for Asian, European and West African populations used in [1], [2].

(Nov.-2010) The genome browser in TIARA supports to browse SNP, short indel, RD (Read Depth) of massively parallel sequencing data, log2 ratio and absolute called log2 ratio [3] of high-resolution CGH array data in whole genome level. In addition, you can also download raw data of sequencing (FASTQ from Illumina Genome Analyzer and csfasta from AB SOLiD), array CGH data (Agilent 24M probes custom-designed array) and genome varaints (SNP, nsSNP, Indel and CNV) of Asian, European and West African population which has been studied on GMI.

In citing TIARA database, please refer to:

Hong,D., Lee,J., Bleazard,T. et al. TIARA genome database: update 2013. Database (Oxford) (2013) Vol. 2013 doi: 10.1093/database/bat003

Hong D, Park S.S., Ju Y.S., Kim S., Shin J.Y., Kim S., Yu SB, Lee W.C., Lee S., Park H., Kim J.I. et al. (2011) TIARA: a database for accurate analysis of multiple personal genomes based on cross-technology, Nucleic Acids Res, 39, D883-888.

Please find [1],[2],[3] and [5] in publication list (see the right board) which introduced the origins of the massively parallel sequencing data (AK series and NA10851), the high-resolution CGH arrays (30 Asians), absolute calling algorithm and genomic variants (SNP, Indel and CNV) of HTS.

The list of sites concerned with TIARA:

CARA (Cgh Array Reference-free Algorithm, http://cara.gmi.ac.kr), Reference-unbiased copy number variant analysis using CGH microarrays, Nucleic Acids Research, 2010, doi: 10.1093/nar/gkq730.

FX (user-Friendly gene eXpression analytics tool, http://fx.gmi.ac.kr), FX: an RNA-Seq analysis tool on the cloud, Bioinformatics, 2012, 10.1093/bioinformatics/bts023.

Publications included in TIARA

Hong D, Lee J, Bleazard T, Jung HC, YS Ju, Yu SB, Kim S, Park SS, Kim JI and Seo JS.
Database (Oxford), 2013, Published Online, Mar 20.
JS Seo, YS Ju, WC Lee, JY Shin, JK Lee, Bleazard T, J Lee, YJ Jung, JO Kim et al.
Genome Research, 2012, Published Online, Sep 13.
Hong D, Rhie A, Park SS, Lee J, Ju YS, Kim S, Yu SB, Bleazard T, Park HS et. al.
Bioinformatics, 2012, Published Online, Jan 17.
Ju YS, Lee WC, Shin JY, Lee S, Bleazard T, Won JK, Kim YT, Kim JI, Kang JH, Seo JS.
Genome Res., 2011, Published Online, Dec 22.
Ju YS, Kim JI, Kim S, Hong D, Park H, Shin JY, Lee S, Lee WC, Kim S, Yu SB, Park SS, et. al.
Nat Genet, 2011; doi:10.1038/ng.872; Epub 2011 July 3.
Hong D, Park SS, Ju YS, Kim S, Shin JY, Kim S, Yu SB, Lee WC, Lee S, Park H, Kim JI, Seo JS.
Nucleic Acids Research, 2010, doi: 10.1093/nar/gkq1101.
Ju YS, Hong D, Kim S, Park SS, Kim S, Lee S, Park H, Kim JI, Seo JS.
Nucleic Acids Research, 2010, doi: 10.1093/nar/gkq730.
Park H, Kim JI, Ju YS, Gokumen O, Mills RE, Kim S, Lee S, Suh D, Hong D et. al.
Nat Genet. 2010 May;42(5):400-5. Epub 2010 Apr 4.
Kim JI, Ju YS, Park H, Kim S, Lee S, Yi JH, Mudge J, Miller NA, Hong D et. al.
Nature 2009 Aug 20; 460(7258):1011-5. Epub 2009 Jul 8.

Genomic Medicine Institute, Seoul National University College of Medicine, 28 Jongno-Gu, Yongon-Dong, Seoul 110-799, Korea